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January 1, 1991Scandinavian Journal of Clinical and Laboratory Investigation18 citations

Impaired left-ventricular function in insulin-dependent diabetic patients with increased urinary albumin excretion

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Why the study?

Is increased urinary albumin excretion associated with impaired left-ventricular function in patients with insulin-dependent diabetes mellitus?

Population

30 patients with insulin-dependent diabetes mellitus and 10 non-diabetic matched controls.

Design

Cross-sectional

Authors

HKHenning KelbækTJT. JensenBFBo Feldt‐Rasmussen

Discussion

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Overview

Links albuminuria to reduced LV volumes in IDDM; hypothesis-generating and leaves causal links open.

Structured PICO

Is increased urinary albumin excretion associated with impaired left-ventricular function in patients with insulin-dependent diabetes mellitus?

P
Population
30 patients with insulin-dependent diabetes mellitus (divided into 3 groups based on urinary albumin excretion) and 10 non-diabetic matched controls (total n=40).
C
Comparator
Non-diabetic matched controls and comparison across diabetic groups with varying albuminuria
O
Outcome
Left-ventricular end-diastolic volume, cardiac output, and stroke volume measured by radionuclide cardiography at rest and during exercisesurrogate

Insulin-dependent diabetic patients with elevated urinary albumin excretion exhibit impaired left-ventricular function, suggesting reduced diastolic compliance.

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Cite This Study

Kelbæk et al. (1991) studied this question.

synapsesocial.com/papers/6a212eae570f73dd9ac3cb55https://doi.org/10.3109/00365519109091641
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased left ventricular systolic function in insulin dependent diabetic patients with normal albumin excretion1998 · 20 citations
  2. 2Left Ventricular Diastolic Impairment in Type 1 Diabetic Patients with Microalbuminuria2008 · 26 citations
  3. 3Impaired Left Ventricular Diastolic Function and Vascular Postischemic Vasodilation Associated with Microalbuminuria in IDDM Patients1995 · 30 citations
  4. 4Cardiac Hyperfunction in Insulin-Dependent Diabetic Patients Developing Microvascular Complications1988 · 38 citations
  5. 5Correlation between albuminuria and tissue <scp>Doppler‐derived</scp> left ventricular myocardial performance index in patients with type 2 diabetes2021 · 4 citations