Key result
Prior AMI, higher LDL, and lower antiplatelet use are linked to AMI in coronary artery ectasia.
Why the study?
Coronary artery ectasia patients are more prone to acute myocardial infarction, but the underlying factors relating to AMI in these patients are not well understood.
What factors are associated with acute myocardial infarction in patients with coronary artery ectasia?
Case-Control (n=119)
No
What factors are associated with acute myocardial infarction in patients with coronary artery ectasia?
In patients with coronary artery ectasia, factors such as prior AMI, lower antiplatelet use, poor lipid control, higher inflammatory response, and Markis type II anatomy are associated with an increased risk of acute myocardial infarction.
May aid risk stratification in coronary artery ectasia; hypothesis-generating and requires prospective validation before practice change.
Coronary artery ectasia (CAE) patients were more prone to present with acute myocardial infarction (AMI), this case-control research aimed to explore the underlying factors relating AMI for them.This study investigated a serial of 119 patients who underwent coronary angiography and were diagnosed as CAE between the years 2016 and 2017 at the Beijing Friendship Hospital; 32 of the patients developed AMI and 87 did not develop AMI. The possible factors relating to AMI, including disease history, cardiovascular risk factors, thrombotic condition, inflammation status, and coronary imaging characteristics, were comprehensively compared between CAE patients with and without AMI.CAE patients with AMI had a lower antiplatelet rate, a higher blood low-density lipoprotein cholesterol level, increased neutrophil to lymphocyte (NL) ratio, higher Gensini score, and larger proportions of Markis type II. Logistic regression analysis also indicated that AMI history, lower antiplatelet rate, higher NL ratio, higher low-density lipoprotein cholesterol level and Gensini score, as well as Markis type II were associated with AMI in CAE patients.AMI history, lower antiplatelet treatment rates, poor blood lipid control and higher coronary stenosis extent, higher inflammatory response, and Markis type II were closely related to the incidence of AMI in CAE patients.
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Sheng et al. (2020) conducted a case-control in Coronary artery ectasia (CAE) (n=119). Risk factors (AMI history, lower antiplatelet rate, higher NL ratio, higher LDL-C, higher Gensini score, Markis type II) vs. CAE patients without AMI was evaluated on Acute myocardial infarction (AMI). In patients with coronary artery ectasia, AMI history, lower antiplatelet rates, higher LDL cholesterol, higher neutrophil-to-lymphocyte ratio, and Markis type II were associated with AMI.
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