Key result
Elevated serum ADMA linked to ~49% greater odds of coronary artery ectasia.
Why the study?
The underlying mechanisms of coronary artery ectasia are unknown, and endothelial dysfunction may play a role as indicated by asymmetric dimethylarginine levels.
Are serum ADMA levels elevated in patients with isolated coronary artery ectasia compared to those with normal coronary arteries?
Case-Control (n=89)
No
Are serum ADMA levels elevated in patients with isolated coronary artery ectasia compared to those with normal coronary arteries?
Serum ADMA levels are significantly elevated in patients with isolated coronary artery ectasia, supporting the hypothesis that endothelial dysfunction is involved in its pathogenesis.
Answers are grounded in this paper and cite their sources.
Supports endothelial dysfunction hypothesis in coronary ectasia; hypothesis-generating and requires prospective validation before clinical use.
Aim: Although underlying mechanisms of coronary artery ectasia (CAE) are clearly unknown, endothelial dysfunction may be responsible for the coronary ectasia. Asymmetric dimethylarginine (ADMA) is the principal endogenous inhibitor of nitric oxide synthase and elevated levels of ADMA is considered to be a marker of endothelial dysfunction and increased risk of cardiovascular disease. Accordingly, we investigated serum ADMA levels in patients with CAE in comparison with participants having normal coronary artery. Method: This study consisted of 41 consecutive patients with angiographically proven normal coronary arteries with CAE and 48 controls with normal coronary arteries without coronary artery ectasia undergoing cardiac catheterization. Serum levels of ADMA were measured by Enzyme Linked Immunosorbent Assay. Result: Serum level of ADMA was significantly higher in CAE patients compared with controls (1.9±0.9 ?mol/l vs. 1.1±0.7 ?mol/l, respectively, p= 0.01). Serum ADMA levels was an independent predictor for CAE (OR= 1.486 [95% confidence interval (CI): 0.978-2.054; p= 0.03]). ADMA levels correlated with diffuse ectasia (p= 0.04). Conclusion: Our findings provide evidence to support the hypothesis that endothelial dysfunction may be an important factor in the pathogenesis of CAE.
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İsmail Erden (2010) conducted a case-control in Isolated Coronary Artery Ectasia (n=89). Elevated serum ADMA levels vs. Normal serum ADMA levels was evaluated on Coronary artery ectasia (OR 1.486, 95% CI 0.978-2.054, p=0.03). Elevated serum asymmetric dimethylarginine (ADMA) levels were an independent predictor for coronary artery ectasia (OR 1.486) and were significantly higher in affected patients compared to controls.
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