November 8, 2005European Heart Journal
Ankle brachial index, C-reactive protein, and central augmentation index to identify individuals with severe atherosclerosis
Key result
ABI <0.70 linked to ~190% greater odds of severe atherosclerosis, unlike CRP and central augmentation index.
- OR 2.9
- 95% CI 1.9-4.6
- P=0.00000003
- n=4,159
Why the study?
The ability of ankle brachial index, C-reactive protein, and central augmentation index to identify individuals with severe atherosclerosis in the general population was examined.
Do ankle brachial index, C-reactive protein, and central augmentation index identify individuals with severe atherosclerosis in the general population?
Population
4159 randomly sampled individuals from the Danish general population, including 250 with severe atherosclerosis
Comparison
Ankle brachial index, C-reactive protein, and central augmentation index measurements
Design
Cross-sectional study
Authors
Discussion
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Member takes
Implication
ABI <0.9 identifies severe atherosclerosis in the general population; leaves open incremental diagnostic value of CRP or augmentation index.
Study Design
Type
Cross-Sectional (n=4,159)
Structured PICO
Do ankle brachial index, C-reactive protein, and central augmentation index identify individuals with severe atherosclerosis in the general population?
P
Population
4,159 randomly sampled individuals from the Danish general population, of which 250 had severe atherosclerosis.
E
Exposure
Measurement of ankle brachial index, C-reactive protein, and central augmentation index
O
Outcome
Presence of severe atherosclerosis (diagnosed as ischaemic cardiovascular disease)
Main Result
Odds Ratio: 2.9 (95% CI 1.9–4.6)
p-value: p=0.00000003
Ankle brachial index <0.9 is a useful clinical tool to identify individuals with severe atherosclerosis in the general population, whereas categorical CRP and central augmentation index are less useful.
Cite This Study
Eldrup et al. (2005) conducted a cross-sectional in Severe atherosclerosis (n=4,159). Ankle brachial index <0.70 vs. Ankle brachial index 0.91-1.10 was evaluated on Severe atherosclerosis (OR 2.9, 95% CI 1.9-4.6, p=0.00000003). Ankle brachial index <0.70 identified individuals with severe atherosclerosis (OR 2.9; 95% CI 1.9-4.6), whereas categorical C-reactive protein and central augmentation index did not.