Key result
Misoprostol blunts ibuprofen-induced GFR decline by ~60% and preserves renal blood flow in diabetic patients.
Why the study?
The acute effects of a PGE1 analog, misoprostol, on NSAID-induced changes in renal blood flow and glomerular filtration rate in diabetic subjects with renal insufficiency were evaluated.
Does misoprostol prevent NSAID-induced reductions in GFR and RBF in diabetic subjects with renal insufficiency taking ibuprofen?
RCT (n=25)
Does misoprostol prevent NSAID-induced reductions in GFR and RBF in diabetic subjects with renal insufficiency taking ibuprofen?
Absolute Event Rate: -10% vs -25%
p-value: p=<0.05
Misoprostol supplementation significantly blunts the acute reduction in renal blood flow and glomerular filtration rate induced by ibuprofen in diabetic patients with renal insufficiency.
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May justify misoprostol co-prescription with ibuprofen in diabetics with renal insufficiency; extends RCT evidence for renoprotection in high-risk NSAID users.
Bakris et al. (1995) conducted an RCT in Renal insufficiency secondary to diabetes (n=25). Misoprostol vs. Placebo was evaluated on Reduction in GFR approximately 2 h after NSAID dose (p=<0.05). Misoprostol significantly attenuated the ibuprofen-induced reduction in glomerular filtration rate (-10 vs -25 mL/min per 1.73 m2; P<0.05) and renal blood flow in diabetic subjects.
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