Dynapenia and diaphragm muscle dysfunction in patients with heart failure

Skeletal muscle dysfunction (dynapenia) is often present in patients with heart failure.1 However, the association of dynapenia with diaphragm muscle dysfunction remains undefined. Sixty-two patients hospitalized for heart failure were enrolled. Diaphragm muscle function was assessed by ultrasonography, and impaired diaphragm function was defined as diaphragm muscle thickness at the end of inspiration below the median value (i.e. <4.0 mm) as previously described.1 Dynapenia was classified into two phenotypes: muscle weakness with low muscle mass (i.e. sarcopenia) and muscle weakness despite normal muscle mass. Muscle weakness and muscle loss were defined according to the criteria of the Asian working group for sarcopenia.1 Dynapenia with muscle loss and dynapenia with normal muscle mass were present in 32.3% and 40.3% of patients, respectively. Compared with patients without dynapenia, patients with either type of dynapenia were older, had significantly reduced knee extensor muscle strength, impaired diaphragm muscle function and a significantly shorter six-minute walk distance (6MWD) (Figure 1(a)). Reduced diaphragm muscle function was associated with a further decrease in the 6MWD of patients with either type of dynapenia (Figure 1(b) and (c)). In multivariate analysis, increased age, reduced diaphragm muscle function and decreased knee extensor muscle strength were independent determinants of short 6MWD in heart failure patients with dynapenia.