Key result
Competing risk nomogram predicts retroperitoneal leiomyosarcoma survival better than the AJCC 8th staging system.
Why the study?
Several prognostic factors might contribute to cancer-specific mortality in patients with retroperitoneal leiomyosarcoma, but a predictive model was lacking.
Observational (n=788)
A novel competing risk-based nomogram accurately predicts cancer-specific survival in patients with retroperitoneal leiomyosarcoma, outperforming the standard AJCC 8th staging system.
Considering the rarity and aggressive nature of retroperitoneal leiomyosarcoma (RLMS), several prognostic factors might contribute to the cancer-specific mortality of these patients. This study aimed to construct a competing risk-based nomogram to predict cancer-specific survival (CSS) for patients with RLMS. In total, 788 cases from the Surveillance, Epidemiology, and End Results (SEER) database (2000-2015) were included. Based on the Fine & Gray's method, independent predictors were screened to develop a nomogram for predicting 1-, 3-, and 5-year CSS. After multivariate analysis, CSS was found significantly associated with tumor characteristics (tumor grade, size, range), as well as surgery status. The nomogram showed solid prediction power and was well calibrated. Through decision curve analysis (DCA), a favorable clinical utility of the nomogram was demonstrated. Additionally, a risk stratification system was developed and distinctive survival between risk groups was observed. In summary, this nomogram showed a better performance than the AJCC 8th staging system and can assist in the clinical management of RLMS.
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Fang et al. (2023) conducted an observational in Retroperitoneal leiomyosarcoma (n=788). Competing risk-based nomogram vs. AJCC 8th staging system was evaluated on 1-, 3-, and 5-year cancer-specific survival (CSS). A competing risk-based nomogram incorporating tumor characteristics and surgery status predicted cancer-specific survival in retroperitoneal leiomyosarcoma better than the AJCC 8th staging system.
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