Clinical Characteristics, Management and Prognosis of Patients with Vaginal Primary Malignant Melanoma

Vaginal primary malignant melanoma (VPMM) is an extremely rare and highly aggressive tumor. It accounts for less than 3% of all vaginal malignancies and 0.3-0.8% of all malignant melanomas. It is the 2nd most common malignant melanoma of the female genital tract. Until today, less than 300 cases of VPMM have been reported in the English literature. The estimated annual incidence of VPMM is 0.026/100,000 women per year. However between various racial or ethnic groups, there are no significant differences in VPMM annual incidence. VPMM most commonly occurs in postmenopausal women. The median age at diagnosis of VPMM, is 57 years