Key result
Schizophrenia is linked to smaller hemodynamic activation in major language centers during expressed emotion stimulations.
Why the study?
The neural substrates responsible for high expressed emotion environments in schizophrenia remain poorly understood.
Do people with schizophrenia show altered cortical hemodynamics during expressed emotion stimulations compared to healthy controls?
Population
People with schizophrenia and healthy controls
Comparison
Novel low- and high-expressed emotion audio stimulations vs healthy controls
Design
Case-control study using fNIRS to measure cortical hemodynamics
Authors
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fNIRS-EE stimuli reveal blunted responses in SZ linked to negative symptoms; hypothesis-generating for vulnerability biomarkers, prospective validation required before clinical use.
Case-Control (n=83)
Single-blind
No
Do people with schizophrenia show altered cortical hemodynamics during expressed emotion stimulations compared to healthy controls?
p-value: p=<0.001
People with schizophrenia show altered and disrupted neural mechanisms, particularly during negative emotional language processing, as measured by fNIRS.
Wang et al. (2023) conducted a case-control in Schizophrenia (n=83). Schizophrenia vs. Healthy controls was evaluated on Hemodynamic activation (HbO) in the left superior temporal gyrus during high expressed emotion stimulations (p=<0.001). Compared to healthy controls, people with schizophrenia exhibited significantly smaller hemodynamic activation in major language centers during expressed emotion stimulations.
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