Key result
Genetic abnormalities are linked to ~4.5-fold higher risk of cardiac complications after conotruncal defect repair.
Why the study?
The effects of genetic abnormalities/syndromes on perioperative outcomes of cardiac surgeries for conotruncal heart defects were not well characterized.
Do genetic abnormalities/syndromes worsen perioperative outcomes in patients undergoing repair of conotruncal heart defects?
Cohort (n=177)
No
Do genetic abnormalities/syndromes worsen perioperative outcomes in patients undergoing repair of conotruncal heart defects?
Answers are grounded in this paper and cite their sources.
Genetic abnormalities and syndromes significantly increase the risk of perioperative cardiac complications, infections, and resource utilization in patients undergoing repair of conotruncal heart defects.
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Lahiri et al. (2019) conducted a cohort in Conotruncal heart defects (CTHD) (n=177). Genetic abnormalities/syndromes (GA/S) vs. No genetic abnormalities/syndromes was evaluated on Post operative length of stay (PLOS) (p=< 0.05). Genetic abnormalities or syndromes in patients undergoing conotruncal heart defect repair were associated with a 4.5-fold higher likelihood of postoperative cardiac complications.
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