Key result
Known genetic diagnoses affect multiple surgical outcomes in congenital heart disease, accounting for 2.5% of the explained variation in surgical outcomes.
Why the study?
To review the current understanding and limitations in knowledge regarding the effect of genetics and genetic diagnoses on perioperative and postoperative surgical outcomes in congenital heart disease.
Does the presence of a genetic diagnosis affect surgical outcomes in patients with congenital heart disease?
Does the presence of a genetic diagnosis affect surgical outcomes in patients with congenital heart disease?
Genetic diagnoses significantly impact surgical outcomes in congenital heart disease, highlighting the need for standardized genetic assessment to improve risk stratification.
Genetic diagnoses may refine risk stratification in congenital heart surgery; leaves open whether routine testing improves outcomes.
PURPOSE OF REVIEW: This article reviews the current understanding and limitations in knowledge of the effect genetics and genetic diagnoses have on perioperative and postoperative surgical outcomes in patients with congenital heart disease (CHD). RECENT FINDINGS: Presence of a known genetic diagnosis seems to effect multiple significant outcome metrics in CHD surgery including length of stay, need for extracorporeal membrane oxygenation, mortality, bleeding, and heart failure. Data regarding the effects of genetics in CHD is complicated by lack of standard genetic assessment resulting in inaccurate risk stratification of patients when analyzing data. Only 30% of variation in CHD surgical outcomes are explained by currently measured variables, with 2.5% being attributed to diagnosed genetic disorders, it is thought a significant amount of the remaining outcome variation is because of unmeasured genetic factors. SUMMARY: Genetic diagnoses clearly have a significant effect on surgical outcomes in patients with CHD. Our current understanding is limited by lack of consistent genetic evaluation and assessment as well as evolving knowledge and discovery regarding the genetics of CHD. Standardizing genetic assessment of patients with CHD will allow for the best risk stratification and ultimate understanding of these effects.
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Geddes et al. (2020) conducted a review in congenital heart disease (CHD). genetic diagnoses was evaluated on perioperative and postoperative surgical outcomes. Known genetic diagnoses affect multiple surgical outcomes in congenital heart disease, accounting for 2.5% of the explained variation in surgical outcomes.
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