Predictions of hypoxaemia at high altitude in children with cystic fibrosis

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Psychotic disorder (n=1). Intervention: Olanzapine. Primary outcome: Pulmonary embolism.

Q: What does this research mean for the field?

Olanzapine treatment may be associated with the development of pulmonary embolism. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

I. M. Waage

doi:10.1136/bmj.327.7428.1384

December 11, 2003BMJOpen Access

Predictions of hypoxaemia at high altitude in children with cystic fibrosis

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Study Design

Type

Case Report (n=1)

Structured PICO

P

Population

A 28-year-old man with a psychotic disorder who developed a pulmonary embolism after 10 weeks of olanzapine treatment.

E

Exposure

Olanzapine started at 10 mg/day and gradually increased to 30 mg/day, co-administered with levomepromazine (50 mg/day), oxazepam (10 mg/day), and flunitrazepam (1 mg/day) for 10 weeks.

O

Outcome

Development of pulmonary embolismsafety

Limitations

Single case report cannot definitively establish causality.
Patient was overweight (BMI 28.5), which is a predisposing condition for venous thrombosis.
Patient was concomitantly taking levomepromazine, oxazepam, and flunitrazepam.

Implication

This case report presents the first described instance of pulmonary embolism possibly associated with olanzapine treatment.

Abstract

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Discussion

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Cite This Study

I. M. Waage (2003) conducted a case report in Psychotic disorder (n=1). Olanzapine was evaluated on Pulmonary embolism.

synapsesocial.com/papers/6aaf98e98fea992f1939a9d2 https://doi.org/10.1136/bmj.327.7428.1384

Topics

Pulmonary embolism

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Predictions of hypoxaemia at high altitude in children with cystic fibrosis

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

Topics

Predictions of hypoxaemia at high altitude in children with cystic fibrosis

Study Design

Structured PICO

Limitations

Implication

Abstract

Discussion

Cite This Study

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