What is the clinical evidence from this study?

Study design: Case Report. Population: Olanzapine overdose (n=1). Intervention: Olanzapine overdose. Primary outcome: Development of acute pericarditis.

November 18, 2025CureusOpen Access

Acute Asymptomatic Pericarditis Following Olanzapine Overdose

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Key result

~300 mg olanzapine overdose linked to acute asymptomatic pericarditis resolving with conservative management.

Why the study?

Acute pericarditis as an early manifestation of olanzapine overdose remains exceedingly rare, and the underlying mechanism is poorly understood.

Population

A male patient in his mid-30s with schizoaffective disorder who ingested approximately 300 mg of olanzapine

Design

Case report

Authors

MRMohsin Ali RazaNebraska Medical Center DBDavid Ballack JKJasleen KaurUniversity of Florida

Discussion

Member takes

Implication

Supports metabolic monitoring with olanzapine; leaves open causal CV risks needing prospective trials.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A male patient in his mid-30s with schizoaffective disorder who developed acute asymptomatic pericarditis following an intentional overdose of approximately 300 mg of olanzapine.

Exposure

Intentional ingestion of approximately 300 mg of olanzapine (30 tablets of 10 mg) in a single sitting.

Outcome

Acute asymptomatic pericarditis detected by electrocardiography (diffuse ST-segment elevations and PR-segment depressions).safety

Olanzapine overdose can cause acute asymptomatic pericarditis, underscoring the importance of routine electrocardiographic monitoring in such scenarios.

Limitations

The patient did not undergo evaluation for eosinophilia, serum IgE levels, or pericardial fluid analysis.
The absence of echocardiographic assessment limits the evaluation of cardiac function and the detection of subtle pericardial effusion.
No evaluation for eosinophilia, serum IgE levels, or pericardial fluid analysis
Absence of echocardiographic assessment to evaluate cardiac function and detect subtle pericardial effusion

Cite This Study

Raza et al. (2025) conducted a case report in Olanzapine overdose (n=1). Olanzapine overdose was evaluated on Development of acute pericarditis. An intentional overdose of approximately 300 mg of olanzapine led to acute asymptomatic pericarditis, evidenced by diffuse ST-segment elevations and PR depressions, which resolved with conservative management.

synapsesocial.com/papers/6a41bb4ec37244ac43773a6e https://doi.org/10.7759/cureus.97165

View Full Paper

Ask AI

Bookmark

Acute Asymptomatic Pericarditis Following Olanzapine Overdose

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Acute Asymptomatic Pericarditis Following Olanzapine Overdose

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider