What does this research mean for the field?

Olanzapine overdose can cause marked bradycardia (41 bpm) in patients, highlighting a rare cardiovascular effect that requires vigilant monitoring. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

This report aims to highlight bradycardia as a rare effect of olanzapine overdose and its clinical implications.

February 9, 2026Clinical Case ReportsOpen Access

Olanzapine Overdose—Induced Bradycardia in a Young Adult With Major Depressive Disorder: A Case Report and Literature Review

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Key result

Olanzapine overdose presents with marked sinus bradycardia without QT prolongation, resolving with supportive care.

Why the study?

Olanzapine overdose is typically associated with tachycardia and QT prolongation, whereas bradycardia remains a rare and underrecognized effect.

Population

A 20-year-old woman with major depressive disorder who ingested 100 mg of olanzapine

Design

Case report and literature review

Follow-up

48 h

Authors

MPMohammad Ghasemi PalangiZanjan University of Medical Sciences HAHassan AhangarZanjan University of Medical Sciences NSNona SakhaieZanjan University of Medical Sciences

Discussion

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Implication

Alerts to possible bradycardia in olanzapine overdose; challenges typical tachycardia/QT profile but hypothesis-generating.

Key Points

This report aims to highlight bradycardia as a rare effect of olanzapine overdose and its clinical implications.
Detailed case report of a young woman with major depressive disorder after olanzapine overdose.
Patient presented 4 hours post-ingestion of 100 mg olanzapine.
Monitoring of heart rate and hemodynamics, alongside supportive care.
The patient exhibited significant bradycardia with a heart rate of 41 bpm.
No QT prolongation was observed during monitoring.
Complete recovery was achieved within 48 hours of supportive treatment.

Structured PICO

Population

1 20-year-old woman with major depressive disorder presenting 4 hours after ingesting 100 mg of olanzapine in a suicide attempt.

Intervention

Supportive care including oxygen, fluids, and cardiac monitoring.

Outcome

Complete recovery from marked sinus bradycardia.safety

Olanzapine overdose can present with isolated, marked sinus bradycardia that resolves completely with supportive care, highlighting an uncommon but important cardiovascular toxicity.

Cite This Study

Palangi et al. (2026) studied this question. A 100 mg olanzapine overdose caused marked sinus bradycardia (41 bpm) without QT prolongation in a young adult, resolving with supportive care within 48 hours.

synapsesocial.com/papers/69897a86f0ec2af6756e8b39 https://doi.org/10.1002/ccr3.71987

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Olanzapine Overdose—Induced Bradycardia in a Young Adult With Major Depressive Disorder: A Case Report and Literature Review

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Olanzapine Overdose—Induced Bradycardia in a Young Adult With Major Depressive Disorder: A Case Report and Literature Review

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider