Key result
In 43 newborns and infants, maternal systemic lupus erythematosus was not associated with significant differences in ventricular function or cardiac conduction system compared to healthy mothers.
Why the study?
Noninvasive cardiac assessment of newborns and infants of women with systemic lupus erythematosus without congenital total atrioventricular block was needed to compare with children of healthy women.
Does maternal systemic lupus erythematosus affect ventricular function or the cardiac conduction system in newborns and infants without congenital total atrioventricular block?
Observational (n=43)
Does maternal systemic lupus erythematosus affect ventricular function or the cardiac conduction system in newborns and infants without congenital total atrioventricular block?
Newborns and infants of women with systemic lupus erythematosus who do not have congenital total AV block show normal ventricular function and cardiac conduction comparable to children of healthy women.
Noninvasive assessment may detect subtle cardiac changes in infants of SLE mothers without AV block; leaves open whether routine screening improves outcomes.
OBJECTIVE: Noninvasive cardiac assessment of newborns and infants of women with systemic lupus erythematosus. The children had no congenital total atrioventricular block and were compared with the children of healthy women. METHODS: We prospectively assessed 13 newborns and infants aged 1 to 60 days, children of women with systemic lupus erythematosus and without congenital total atrioventricular block. These children were compared with 30 children of women who had no lupus or anti-Ro/SSA antibodies, and no risk factors for congenital heart disease either. Their age groups matched. The following examinations were performed: cardiological physical examination, electrocardiography, echocardiography, and signal-averaged electrocardiography. RESULTS: The statistical analysis showed no significant difference in ventricular function or in the cardiac conduction system between the groups. CONCLUSION: In regard to the conduction system and ventricular function in the absence of total atrioventricular block, no statistically significant difference was observed between the children of women with systemic lupus erythematosus and children of healthy women.
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Leite et al. (2003) conducted an observational in Maternal systemic lupus erythematosus (n=43). Maternal systemic lupus erythematosus vs. Children of healthy women was evaluated on Ventricular function and cardiac conduction system. In 43 newborns and infants, maternal systemic lupus erythematosus was not associated with significant differences in ventricular function or cardiac conduction system compared to healthy mothers.
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