A water extract of the Oriental crude drug “reishi”, the fruit bodies of Ganoderma lucidum , significantly decreased plasma sugar level in mice. Fractionation of the extract by monitoring the hypoglycemic activity afforded two glycans, ganoderans A and B. These glycans elicited remarkable hypoglycemic actions in normal and alloxan-induced hyperglycemic mice. 1 Antidiabetes drugs, Part 9. Also Part 91 in the validity of the Oriental medicines
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Hikino et al. (1985) studied this question.