The inhibitory peptides of angiotensin I-converting enzyme have been identified from cottonseed proteins. The inhibitory peptides in the pepsin hydrolyzate of cottonseed globulin were purified by successive chromatographies on CM-Sephadex C-50, Sephadex LH-20, and reversed phase high performance liquid chromatography using a C18 column. The amino acid sequences of inhibitory peptides were Tyr-Arg-Lys-Ile-Arg-Ser-Gln-Leu and Trp-Gln-His-Gln-Ser-Arg-Gly-Arg-Phe. The IC50 value of the former peptide was 3.8 μM and the latter was 27 μM.
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Ashida et al. (1997) studied this question.
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