Key result
Male sex, symptom history under three months, and absent throat symptoms predict globus pharyngeus improvement.
Why the study?
Long-term prognosis and factors influencing outcome in patients with globus pharyngeus were not well characterized.
What is the long-term prognosis and what are the prognostic factors for patients with globus pharyngeus?
Cohort (n=80)
What is the long-term prognosis and what are the prognostic factors for patients with globus pharyngeus?
p-value: p=<0.05
In patients with globus pharyngeus, male sex, short symptom history, and lack of associated throat symptoms predict a better chance of symptomatic improvement over long-term follow-up.
May inform counseling on globus pharyngeus prognosis; hypothesis-generating and requires prospective validation.
A prospective trial of 80 patients with globus pharyngeus is reported. An in-depth analysis of the typical history at presentation is given. The average follow-up period was 27 months (range, 21 to 42 months). The asymptomatic rate at this interval was 25%, with a further 35% reporting a significant improvement in symptoms. Three independent factors were found to influence prognosis (p less than .05). These were sex, length of history at consultation, and the presence or absence of associated throat symptoms. Male patients having a history of the globus symptom for less than 3 months and not complaining of any associated throat symptoms had the best chance of becoming asymptomatic or symptomatically improved. The presence or absence of heartburn or its treatment had no bearing on outcome.
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Timon et al. (1991) conducted a cohort in Globus pharyngeus (n=80). Prognostic factors (sex, length of history, associated throat symptoms) was evaluated on Asymptomatic rate or significant improvement in symptoms (p=<0.05). Male sex, symptom history <3 months, and absence of associated throat symptoms were independent prognostic factors for becoming asymptomatic or improved in patients with globus pharyngeus (p<0.05).
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