Global prevalence of acceptance of COVID-19 vaccines and associated factors in pregnant women: a systematic review and meta-analysis

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INTRODUCTION: We performed a systematic review and meta-analysis to evaluate the acceptance of a COVID-19 vaccine among pregnant women and its determinants. METHOD: We searched the bibliographic databases (Scopus, Medline, and Web of Science) for the relevant studies from 1 January 2020 to 11 July 2021. We pooled the prevalence of vaccine acceptance among pregnant women using a random-effects model and conducted subgroup analyses to explore its determinants. The result was expressed as a pooled prevalence percentage and adjusted odds ratio (aOR) with 95% CIs. RESULTS: We found ten studies that were suitable, with 16, 696 participants from 32 countries. COVID-19 vaccination acceptability in pregnant women was 54 percent globally (95% CI: 45, 62; I2= 99.05). There was no association between sociodemographic factors including age >35 years (aOR: 1.17, 95%CI: 0.95, 1.43), high education (aOR: 1.03, 95%CI: 0.79, 1.35), income levels (aOR: 1.18, 95%CI: 0.80, 1.75), knowledge scores (aOR: 2.55, 95% CI: 0.78, 8.34) and COVID-19 vaccine acceptance. CONCLUSION: About half of pregnant women accepted the COVID-19 vaccine. We did not find any association between sociodemographic factors and COVID-19 vaccine acceptance. However, these findings should be considered with caution due to small number of studies and the substantial heterogeneity between them.