Software development report demonstrates functional gene enrichment analysis across over 200 plant and animal species, highlighting streamlined visualization of molecular pathways.
Motivation Gene lists are routinely produced from various genome-wide studies. Enrichment analysis can link these gene lists with underlying molecular pathways by using functional categories such as gene ontology (GO). Results To complement existing tools, we developed ShinyGO with several features: (1) large annotation database from GO and many other sources for over 200 plant and animal species, (2) graphical visualization of enrichment results and gene characteristics, and (3) application program interface (API) access to KEGG and STRING for the retrieval of pathway diagrams and protein-protein interaction networks. ShinyGO is an intuitive, graphical web application that can help researchers gain actionable insights from gene lists. Availability http://ge-lab.org/go/ Contact gexijin@gmail.com Supplementary information Supplementary data are available at Bioinformatics online.
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Ge et al. (2018) studied this question.
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