Key result
Epinephrine directly induces platelet aggregation and fibrinogen receptor exposure independent of other excitatory agonists.
Why the study?
Previous measurements in platelet-rich plasma or washed platelets failed to define whether epinephrine directly induces fibrinogen receptor exposure and platelet aggregation in whole blood.
Does epinephrine directly induce platelet fibrinogen receptor expression and aggregation in whole blood independent of other agonists?
Does epinephrine directly induce platelet fibrinogen receptor expression and aggregation in whole blood independent of other agonists?
p-value: p=<.001
Epinephrine directly induces platelet fibrinogen receptor exposure and aggregation in whole blood, independent of other excitatory agonists.
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Animal data on epinephrine-platelet effects require human validation; leaves open clinical relevance to thrombosis.
Shattil et al. (1989) studied this question. Epinephrine was evaluated on FITC-PAC1 binding (fibrinogen receptor exposure) (p=<.001). Epinephrine directly induced significant platelet fibrinogen receptor exposure (P<.001), fibrinogen binding, and aggregation in whole blood independent of other excitatory agonists.
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