What does this research mean for the field?

Slowly adhering cardiac mesenchymal cells isolated solely by plastic adherence improve left ventricular ejection fraction and attenuate adverse remodeling after myocardial infarction in mice. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess the therapeutic and myocardial reparative capabilities of cardiac mesenchymal cells isolated via standard plastic adherence.

September 20, 2026Journal of the American College of CardiologyOpen Access

Myocardial Reparative Properties of Cardiac Mesenchymal Cells Isolated on the Basis of Adherence

Q: What are the key findings of this study?

In mice subjected to myocardial infarction, treatment with slowly adhering cardiac mesenchymal cells significantly increased left ventricular ejection fraction at 28 days compared to vehicle (31.2% vs 24.7%; p<0.05).

Q: What is the clinical evidence from this study?

Study design: Other. Population: Myocardial infarction. Intervention: Slowly adhering (SA) cardiac mesenchymal cells (CMCs) vs. Vehicle and rapidly adhering (RA) CMCs. Primary outcome: Left ventricular ejection fraction at 28 days (p=< 0.05).

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Key result

Slowly adhering cardiac mesenchymal cells improve LVEF by ~7% versus vehicle in mice post-MI.

P<0.05

Authors

MWMarcin WysoczynskiUniversity of Louisville YGYiru GuoUNSW Sydney JMJoseph B. MooreUniversity of Louisville

Discussion

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Implication

Experimental study demonstrates myocardial reparative capacity of adherence-isolated cardiac mesenchymal cells, indicating potential for targeted cardiac cell therapy.

Key Points

To assess the therapeutic and myocardial reparative capabilities of cardiac mesenchymal cells isolated via standard plastic adherence.
Isolated cardiac mesenchymal cells from cardiac tissue using adherence-based culture protocols.
Characterized cellular phenotypes and evaluated functional reparative properties in myocardial repair models.
Adherence-isolated cardiac mesenchymal cells exhibited phenotypic properties supportive of myocardial preservation and repair.
Functional assessments showed qualitative improvements in tissue reparative activity associated with cell administration.

PICO

Population

Mice subjected to myocardial infarction and treated with cardiac mesenchymal cells 2 days post-MI, evaluated at 28 days.

Intervention / Comparator

Slowly adhering (SA) cardiac mesenchymal cells (CMCs) vs Vehicle and rapidly adhering (RA) CMCs

Primary Outcome

Left ventricular ejection fraction at 28 days, p=< 0.05

Main Result

Absolute Event Rate: 31.2% vs 24.7%

p-value: p=< 0.05

Cite This Study

Wysoczynski et al. (2017) studied Myocardial infarction. Slowly adhering (SA) cardiac mesenchymal cells (CMCs) vs. Vehicle and rapidly adhering (RA) CMCs was evaluated on Left ventricular ejection fraction at 28 days (p=< 0.05). In mice subjected to myocardial infarction, treatment with slowly adhering cardiac mesenchymal cells significantly increased left ventricular ejection fraction at 28 days compared to vehicle (31.2% vs 24.7%; p<0.05).

synapsesocial.com/papers/6aafa45857d6df4e8ab04a3a https://doi.org/10.1016/j.jacc.2017.01.048

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Implication

Experimental study demonstrates myocardial reparative capacity of adherence-isolated cardiac mesenchymal cells, indicating potential for targeted cardiac cell therapy.

Myocardial Reparative Properties of Cardiac Mesenchymal Cells Isolated on the Basis of Adherence

Discussion

Member takes

Implication

Key Points

PICO

Main Result

Cite This Study

Myocardial Reparative Properties of Cardiac Mesenchymal Cells Isolated on the Basis of Adherence

Discussion

Member takes

Implication

Key Points

PICO

Main Result

Cite This Study

Also Consider

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