What is the clinical evidence from this study?

Study design: Observational. Population: Atherosclerotic coronary arteries and saphenous vein bypass grafts. Intervention: Balloon-expandable flexible coil stent (Cook). Primary outcome: Morphologic changes and vessel patency.

What does this research mean for the field?

Placement of a balloon-expandable flexible coil stent maintains vessel patency with reendothelialization and minimal tissue inflammatory reaction despite postangioplasty lumen disruption. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 20, 2026Journal of the American College of CardiologyOpen Access

Vascular pathology of balloon-expandable flexible coil stents in humans

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Key result

Balloon-expandable flexible coil stents maintain vessel patency with minimal inflammation despite lumen disruption.

Why the study?

The morphologic changes and vascular response after placement of balloon-expandable flexible coil stents in atherosclerotic coronary arteries and saphenous vein bypass grafts were not well described.

Authors

PAPeter G. Anderson RBRavi K. BajajUniversity of Kansas WBWilliam A. BaxleyUniversity of Alabama at Birmingham

Discussion

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Implication

Pathological evaluation demonstrates maintained patency and minimal inflammation after flexible coil stent placement in diseased human vessels, indicating high vascular biocompatibility.

Key Points

To assess the histopathological and morphologic responses of human coronary arteries and saphenous vein bypass grafts following balloon-expandable flexible coil stent implantation.
Examined post-implantation vascular tissue morphology and host responses in atherosclerotic human coronary arteries and saphenous vein bypass grafts fitted with Cook flexible coil stents.
Stented vessels maintained continuous lumen patency despite histological evidence of vessel wall injury and dissection from angioplasty.
The stented regions underwent reendothelialization, with smooth muscle cells primarily forming the tissue layer covering the metallic stent wires.
Surrounding vascular tissue exhibited minimal inflammatory reaction to the metallic prosthesis across all evaluated specimens.

Study Design

Type

Observational

PICO

Population

Atherosclerotic coronary arteries and saphenous vein bypass grafts

Exposure / Comparator

Balloon-expandable flexible coil stent (Cook)

Primary Outcome

Morphologic changes and vessel patency

Cite This Study

Anderson et al. (1992) conducted an observational in Atherosclerotic coronary arteries and saphenous vein bypass grafts. Balloon-expandable flexible coil stent (Cook) was evaluated on Morphologic changes and vessel patency. Placement of a balloon-expandable flexible coil stent maintained vessel patency with reendothelialization and minimal inflammatory reaction despite postangioplasty lumen disruption.

synapsesocial.com/papers/6ab04d17cdc128587b47ec9c https://doi.org/10.1016/0735-1097(92)90494-8

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Implication

Pathological evaluation demonstrates maintained patency and minimal inflammation after flexible coil stent placement in diseased human vessels, indicating high vascular biocompatibility.

Vascular pathology of balloon-expandable flexible coil stents in humans

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

Vascular pathology of balloon-expandable flexible coil stents in humans

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Cite This Study

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