Editorial: From vulnerability to vigor: innovative approaches in frailty and healthy aging

Frailty is a significant factor contributing to adverse events, particularly among older adults (1). The presence of various comorbidities can influence levels of frailty and the ability to maintain autonomy (2).Frail older adults typically exhibit lower physical and cognitive functions, which leads to a higher risk of mortality, hospitalization, and complications during procedures (3). Therefore, a personalized treatment approach may be the most effective way to reverse frailty and enhance functional capabilities (4).The present research topic has been titled: "From Vulnerability to Vigor: Innovative Approaches in Frailty and Healthy Aging".In particular, Domenica Francesca Mariniello et al. found that frailty was associated with poorer lung function and greater physical impairment in patients with fibrotic interstitial lung diseases receiving antifibrotic therapy. Moreover, frail subjects required attention to find the right dosage. Beyond clinical and functional scores, circulating biomarkers are increasingly investigated as complementary tools to capture the biological underpinnings of frailty and support earlier, more objective risk stratification (5).Based on the published papers mentioned earlier, we can infer that frail patients often have multiple comorbidities that can negatively affect their physical and cognitive status. Physical therapy and rehabilitation can be treatment options for some frail older patients, but there is currently no approved medication specifically for frailty (6).Many studies suggest using nutraceuticals to enhance the functional status of frail individuals (7).Studies recommend using sodium-glucose co-transporters 2 (SGLT2) inhibitors for patients with comorbidities such as diabetes, chronic kidney disease, and heart failure because their pleiotropic effects (8,9).Metformin is recommended for frail diabetic and prediabetic patients due to its anti-aging properties (10).Thus, careful prevention is vital for promoting healthy aging. Frail patients should receive individualized treatment tailored to their comorbidities and functional status.