Key result
Multi-tyrosine kinase inhibitors show no increased risk of ischemic or cerebrovascular events versus matched non-cancer controls.
Why the study?
Cardiovascular toxicity of patients treated with small molecule tyrosine kinase inhibitors remains unclear despite common warnings of cardiovascular events in drug labels.
Do small molecule tyrosine kinase inhibitors increase the risk of ischemic heart disease, cerebrovascular accidents, and death in adults with advanced malignancy?
Population
1642 adults with advanced malignancy in Ontario, Canada
Comparison
Patients treated with TKIs vs age and gender-matched individuals without cancer
Design
Population-based observational cohort study
Follow-up
Median 380 days (range 6-1970 days)
Authors
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In a real-world population of patients with advanced solid tumors, treatment with tyrosine kinase inhibitors did not increase the risk of ischemic heart disease or cerebrovascular accidents compared to matched controls without cancer.
Cohort (n=130,057)
Do small molecule tyrosine kinase inhibitors increase the risk of ischemic heart disease, cerebrovascular accidents, and death in adults with advanced malignancy?
Hazard Ratio: 0.82 (95% CI 0.52–1.3)
p-value: p=0.4
In a real-world population of patients with advanced solid tumors, treatment with tyrosine kinase inhibitors did not increase the risk of ischemic heart disease or cerebrovascular accidents compared to matched controls without cancer.
Srikanthan et al. (2015) conducted a cohort in Advanced Solid Tumors (n=130,057). Multi-Tyrosine Kinase Inhibitors vs. Age and gender-matched individuals without cancer was evaluated on Ischemic heart events (acute myocardial infarction and angina) (HR 0.82, 95% CI 0.52-1.30, p=0.4). Multi-tyrosine kinase inhibitors did not significantly increase the hazard of ischemic heart events (HR 0.82) or cerebrovascular accidents compared to matched individuals without cancer.
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