Key result
OSA and OHS linked to impaired global myocardial performance, including worse GLS and TAPSE.
Why the study?
Sleep related breathing disorders can be complicated by cardiovascular complications, but the impact of chronic intermittent hypoxia and nocturnal hypercapnia on global myocardial performance is not well defined.
Does the presence of OSA or OHS impair global myocardial performance in adult patients?
Case-Control (n=142)
No
Does the presence of OSA or OHS impair global myocardial performance in adult patients?
p-value: p=<0.05
Sleep-related breathing disorders, specifically OSA and OHS, are associated with subclinical global myocardial dysfunction and regional strain abnormalities, highlighting the cardiovascular impact of chronic intermittent hypoxia and nocturnal hypercapnia.
May warrant cardiac evaluation in OSA/OHS; leaves open whether treatment improves myocardial performance.
Background: Sleep related breathing disorders (SRBDs) are disorders caused by a decline or interruption in breathing during sleep and can be complicated by cardiovascular complications. Objective: The aim of this study was to evaluate the impact of chronic intermittent hypoxia and nocturnal hypercapnia on global myocardial performance utilizing different modes of echocardiography in patients with SRBDs. Methods: This a case control study was conducted on 142 adult subjects who attended to outpatient clinics and Mansoura university sleep center, Egypt during the period study from august 2016 till august 2018. Results: There were statistically significant higher BMI and NC in patients with OSA, OHS groups versus the control group (p<0.001). Comparing OSA& OHS groups with control group, statistically significant difference regarding each of MPI, GLS, TAPSE (mm) and grade of DD by TDI (p<0.05), GLS, TAPSE (mm) and grade of DD by TDI respectively. Speckle tracking echocardiography showed statistically significant differences all over the 17 segment of the LV and the most affected segments are Inferolateral, Inferior and Inferoseptal and showed that basal segments more affected than mid and apical segments.Conclusion: there is cardiovascular comorbidity associated with chronic intermittent hypoxia and nocturnal hypercapnia in patients with OSA and OHS.
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Shabana et al. (2022) conducted a case-control in Sleep related breathing disorders (Obstructive Sleep Apnea and Obesity Hypoventilation Syndrome) (n=142). Sleep related breathing disorders with nocturnal hypoxia and hypercapnia vs. Healthy controls without sleep related breathing disorders (AHI < 5) was evaluated on Global myocardial performance (including Myocardial Performance Index, Global Longitudinal Strain, TAPSE, and diastolic dysfunction) (p=<0.05). Patients with obstructive sleep apnea and obesity hypoventilation syndrome exhibited significantly impaired global myocardial performance, including worse global longitudinal strain and tricuspid annular plane systolic excursion, compared to healthy controls.
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