Key result
Non-invasive His bundle recordings succeed in ~45% of patients and strongly correlate with invasive intervals.
Why the study?
The second generation MAC-1 ECG cart includes technical advances that may enable clinically applicable non-invasive His bundle electrogram recording, addressing prior limitations.
Does the Marquette high resolution MAC-1 ECG cart accurately record the His bundle electrogram non-invasively compared to invasive methods?
Observational (n=55)
Does the Marquette high resolution MAC-1 ECG cart accurately record the His bundle electrogram non-invasively compared to invasive methods?
The high-resolution MAC-1 ECG cart can non-invasively record His bundle electrograms with high correlation to invasive measurements, though clinical utility is limited by a 55% failure rate.
Answers are grounded in this paper and cite their sources.
High correlation supports technical feasibility of noninvasive HV recording; leaves open clinical adoption given 55% failure rate.
The Marquette high resolution MCA-1 ECG cart can record the His bundle electrogram non-invasively at the bedside. The second generation MAC-1 has several unique features and technical advances which may now make the technique clinically applicable. In addition to amplification and signal averaging, an adjustable input filtration system excludes beats which are unacceptably "noisy" compared to a 4 beat template. Thus, extremely "clean" signals are presented for processing by the average allowing resolution of very low amplitude signals. Clear unequivocal His bundle recordings were obtainable in 25 of 55 patients (45%). A correlation coefficient of +.97 was obtained between invasive and non-invasive HV intervals. The 55% failure rate was attributed to prolonged atrial activity in 31%, short PR in 9%, and technically unsatisfactory recordings with excessive or overwhelming noise which did not allow appreciable signal resolution in 15%.
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MacGregor et al. (1980) reported an observational. Marquette high resolution MCA-1 ECG cart vs. Invasive His bundle electrogram was evaluated on Clear unequivocal His bundle recordings (correlation coefficient +0.97). Non-invasive His bundle recordings using the Marquette MCA-1 ECG cart were obtainable in 45% of patients, demonstrating a +0.97 correlation with invasive HV intervals.
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