Key result
High-intensity exercise fails to significantly increase prefrontal oxygenation vs moderate intensity in methamphetamine users.
Why the study?
The influence of different intensities of acute aerobic exercise on brain activation in male methamphetamine-dependent patients was unclear.
Does high-intensity aerobic exercise improve cerebral oxygenation in the prefrontal cortex of male methamphetamine-dependent patients compared to moderate-intensity exercise?
RCT (n=20)
Open-label
Randomly divided
No
Does high-intensity aerobic exercise improve cerebral oxygenation in the prefrontal cortex of male methamphetamine-dependent patients compared to moderate-intensity exercise?
High-intensity aerobic exercise may provide greater cerebral oxygenation benefits in the prefrontal cortex for male methamphetamine-dependent patients compared to moderate-intensity exercise.
Answers are grounded in this paper and cite their sources.
May favor high-intensity aerobic exercise to maximize acute prefrontal oxygenation in male methamphetamine-dependent patients; extends RCT evidence on exercise dosing in addiction.
The aim of this study was to explore the influence of different intensities of acute aerobic exercise on brain activation in male methamphetamine (MA)-dependent patients during exercise. Twenty MA-dependent patients were divided randomly into two groups participating in 35 min of either moderate- or high-intensity aerobic exercise. Functional near-infrared spectral imaging (fNIRS) was used to detect hemodynamic changes in prefrontal cortex during the main 25-min exercise stage. The results revealed that high-intensity acute aerobic exercise aroused more cerebral oxygenation changes in the prefrontal cortex and left dorsolateral prefrontal cortex during exercise as compared with moderate-intensity exercise. Furthermore, there was a stronger positive connection observed between orbital frontal cortex and left dorsolateral prefrontal cortex in the high-intensity group than in the moderate-intensity group. Together these results suggest that for submaximal exercise intensities, high-intensity exercise may bring more benefits to male MA-dependent patients than moderate-intensity.
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Gao et al. (2022) conducted an RCT in Methamphetamine dependence (n=20). High-intensity acute aerobic exercise vs. Moderate-intensity acute aerobic exercise (65-75% of HRmax) was evaluated on Mean oxygenated hemoglobin ([HbO]) concentration changes in the prefrontal cortex during 25-minute exercise (p=0.063). High-intensity acute aerobic exercise induced greater cerebral oxygenation changes in the prefrontal cortex compared to moderate-intensity exercise in male methamphetamine-dependent patients.
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