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Unite in times of deprivation: We report on the use of a chemostat to elicit cryptic biosynthetic pathways in a fungus. Cutlivation of Aspergillus nidulans under N-limiting conditions in a chemostat led to the specific induction of polyketide biosynthesis genes that were otherwise silent. The merger of an anthraquinone with an orsellinic acid-derived oxanthrene yielded two spiroanthrones, sanghaspirodins A and B (see figure).
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Scherlach et al. (2011) studied this question.
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