Why the study?
The association of PPAR delta -87T/C polymorphism with sugar metabolism indices and TNFα levels in T2DM and normal fasting glucose subjects was unclear.
Is the PPAR delta -87T/C polymorphism associated with sugar metabolism indices and TNF alpha levels in patients with T2DM and normal fasting glucose?
Case-Control (n=444)
Is the PPAR delta -87T/C polymorphism associated with sugar metabolism indices and TNF alpha levels in patients with T2DM and normal fasting glucose?
p-value: p=0.994
The PPAR delta -87T/C polymorphism is associated with variations in glucose, lipid metabolism, and TNFα levels among patients with type 2 diabetes, despite similar genotype frequencies compared to healthy controls.
Genotype frequencies are similar between T2DM and controls; leaves open functional effects on metabolism and inflammation in diabetes.
This study aims to investigate the association of peroxisome proliferator-activated receptor (PPAR) delta -87T/C polymorphism with several sugar metabolism indices and tumor necrosis factor α (TNF α) level. The body mass index (BMI), waist size, and levels of fasting plasma glucose, serum lipid, fasting insulin, TNFα, and PPAR delta -87T/C of 286 patients with type 2 diabetes mellitus (T2DM) and 158 subjects with normal fasting glucose (NFG) were measured in a Dalian population. The distribution of genotypic frequencies between T2DM and NFG were not significantly different (χ(2) = 0.012, P = 0.994). BMI, fasting blood glucose (FBG), homeostasis model assessment-estimated insulin resistance (HOMA-IR), triglyceride, and TNFα levels were significantly different among different T2DM genotypes. HOMA-IR and FBG were significantly different among different NFG genotypes. The PPAR delta -87T/C polymorphism is known to be closely related with glucose levels and lipid metabolism. A close relationship was also found between HOMA-IR and TNFα levels and HOMA-IR and FBG in T2DM and NFG, respectively.
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Yu et al. (2014) conducted a case-control in Type 2 diabetes mellitus (n=444). PPAR delta -87T/C polymorphism vs. Normal fasting glucose subjects was evaluated on Distribution of genotypic frequencies between T2DM and NFG (p=0.994).
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