January 25, 2003Clinical Chemistry and Laboratory Medicine (CCLM)Open Access

The TNF- α Gene NcoI Polymorphism at Position –308 of the Promoter Influences Insulin Resistance, and Increases Serum Triglycerides after Postprandial Lipaemia in Familiar Obesity

View Full Paper

Ask AI

Bookmark

Why the study?

Does the TNF-alpha -308 A/G polymorphism influence insulin resistance and postprandial lipaemia in obese individuals?

Population

121 Polish Caucasian subjects (38 men, 83 women) representing 40 obese families

Comparison

TNF-2 allele carriers vs TNF-1 (GG) allele carriers

Design

Cross-sectional

Authors

IWIwona WybrańskaJagiellonian University MMMałgorzata Malczewska-MalecJagiellonian University SNS Niedbał

Discussion

Member takes

Implication

Sex-specific TNF-2 associations with insulin resistance and lipemia in obesity should not change practice; leaves open causal role pending prospective studies.

Structured PICO

Does the TNF-alpha -308 A/G polymorphism influence insulin resistance and postprandial lipaemia in obese individuals?

Population

121 Polish Caucasian subjects (38 men, 83 women) representing 40 obese families

Intervention

TNF-2 (GA and AA) allele carriers (A/G variation at position -308 in the TNF-alpha promoter)

Comparator

TNF-1 (GG) allele carriers

Outcome

Insulin resistance parameters (HOMA-IR, ISI-COMP, ISI-HOMA, DELTA), body weight, and postprandial lipaemiasurrogate

The TNF-alpha -308 A/G polymorphism is associated with increased insulin resistance in obese women and elevated postprandial triglycerides and free fatty acids in obese men.

Cite This Study

Wybrańska et al. (2003) studied this question.

synapsesocial.com/papers/6a6fb9daa528af2d65c321e8 https://doi.org/10.1515/cclm.2003.076

View Full Paper

Ask AI

Bookmark

Implication

Sex-specific TNF-2 associations with insulin resistance and lipemia in obesity should not change practice; leaves open causal role pending prospective studies.

The TNF- α Gene NcoI Polymorphism at Position –308 of the Promoter Influences Insulin Resistance, and Increases Serum Triglycerides after Postprandial Lipaemia in Familiar Obesity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The TNF- α Gene NcoI Polymorphism at Position –308 of the Promoter Influences Insulin Resistance, and Increases Serum Triglycerides after Postprandial Lipaemia in Familiar Obesity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider