What is the clinical evidence from this study?

Study design: Cohort. Population: Insulin resistance syndrome (n=1163). Intervention: TNF2 allele vs. Homozygotes for the wild-type allele. Primary outcome: Levels, 10-year change, and clustering of components of the insulin resistance syndrome.

What question did this study set out to answer?

This research aims to determine if the TNF2 polymorphism of the TNF-α gene affects insulin resistance components and their clustering.

February 12, 2026Journal of Investigative Medicine

Lack of Association between the -308 Polymorphism of the Tumor Necrosis Factor-α Gene and the Insulin Resistance Syndrome

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Key result

TNF2 allele shows no association with insulin resistance syndrome components or their 10-year progression.

n=1,163

Why the study?

Is the TNF2 allele associated with altered levels or clustering of components of the insulin resistance syndrome in young adults?

Population

1,163 African American and white men and women aged 18-30 from the Coronary Artery Risk Development in…

Comparison

Carriers of the TNF2 allele vs Homozygotes for the wild-type allele

Design

Cohort

Follow-up

10 years

Authors

BSBárbara da SilvaNorthwestern University SGS. M. GapsturNorthwestern University YAYoung-Hie AchenbachNorthwestern University

Discussion

Member takes

Implication

The TNF2 allele is not associated with the development or clustering of insulin resistance syndrome components over 10 years in young adults.

Key Points

This research aims to determine if the TNF2 polymorphism of the TNF-α gene affects insulin resistance components and their clustering.
Analyzed components of insulin resistance syndrome including insulin levels, BMI, and cholesterol.
Conducted in a subsample of the CARDIA study with diverse participants ages 18-30.
Typed participants for the TNF-α locus to assess genotype association.
TNF2 allele frequency was 12% in blacks and 16% in whites.
No differences in insulin resistance components were observed between TNF2 carriers and wild-type homozygotes at baseline or after 10 years.
No clustering of insulin resistance components was noted among TNF2 allele carriers.

Study Design

Type

Cohort (n=1,163)

Structured PICO

Is the TNF2 allele associated with altered levels or clustering of components of the insulin resistance syndrome in young adults?

Population

1,163 African American and white adults aged 18-30 from the CARDIA study, followed for 10 years to assess the association between the TNF2 allele and insulin resistance syndrome.

Exposure

Carriers of the TNF2 allele (-308 polymorphism of the TNF-α gene)

Comparator

Homozygotes for the wild-type allele

Outcome

Levels of components of the insulin resistance syndrome (fasting insulin, BMI, systolic blood pressure, triglycerides, uric acid, HDL-cholesterol), clustering of these components, and 10-year changesurrogate

The TNF2 allele is not associated with the development or clustering of insulin resistance syndrome components over 10 years in young adults.

Cite This Study

Silva et al. (2000) conducted a cohort in Insulin resistance syndrome (n=1,163). TNF2 allele vs. Homozygotes for the wild-type allele was evaluated on Levels, 10-year change, and clustering of components of the insulin resistance syndrome. The TNF2 allele (frequency 12% in blacks, 16% in whites) was not associated with differences in the level, 10-year change, or clustering of components of the insulin resistance syndrome.

synapsesocial.com/papers/698d6e055be6419ac0d5359a https://doi.org/10.1177/108155890004800404

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Implication

The TNF2 allele is not associated with the development or clustering of insulin resistance syndrome components over 10 years in young adults.

Lack of Association between the -308 Polymorphism of the Tumor Necrosis Factor-α Gene and the Insulin Resistance Syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Lack of Association between the -308 Polymorphism of the Tumor Necrosis Factor-α Gene and the Insulin Resistance Syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Also Consider