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Ammonium- and imidazolium-based ionic salts were studied for their application as inhibitors of HIV-1 integrase (IN). These compounds were active in the inhibition of both the 3′-processing (3′-P) and strand transfer (ST) steps of the integration reaction. A correlation of activity with chain length of the alkyl substituent in both classes of ionic salts was observed.
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Maddali et al. (2010) studied this question.
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