Hydrotropes enhance solubility of water-insoluble or sparingly soluble solutes such as o - and p -hydroxyacetophenones (HAPs) in aqueous solutions. The solubility of HAPs is experimentally determined in aqueous solutions of sodium cumene sulfonate (NaCS), sodium p -xylene sulfonate (NaXS), and sodium p -toluene sulfonate (NaPTS). The solubility of phenols increases almost by an order of magnitude at higher concentrations of the hydrotropes in the order NaPTS, NaXS, and NaCS, at a given temperature. The solubility o -HAP was twice that of p -HAP in the NaCS solutions, and a similar trend was observed in other hydrotrope solutions. The solubility data was fitted in the Association model of hydrotropy to estimate the hydrotrope−hydrotrope and hydrotrope−solute interaction parameters. NaCS, the more hydrophobic hydrotrope, shows stronger interaction with the phenols and a higher association constant.
No takes yet. Share an insight, caveat, or question.
Koparkar et al. (2004) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: