Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an in vitro study

OBJECTIVES: In this study, we investigated the potential of amoxicillin-loaded polymeric microspheres to be delivered to tooth root infection sites via a bioactive reparative cement. MATERIALS AND METHODS: for physical and mechanical eligibility. The morphology of microspheres was observed under scanning electron microscopy. CONCLUSIONS: Lack of optimal concentrations of antibiotics at anatomical sites of the dental tissues is a hallmark of recurrent endodontic infections. Therefore, targeting the controlled release of broad-spectrum antibiotics may improve the therapeutic outcomes of current treatments. Overall, these results indicate that the carry of amoxicillin by microspheres could provide an alternative strategy for the local delivery of antibiotics for the management of tooth infections.