Key result
Seminal plasma metabolomics identifies 41 metabolites differentiating infertile males with Kidney-Yang Deficiency from fertile males.
Why the study?
Traditional Chinese medicine treatment for male infertility depends on differentiation of TCM syndromes, but metabolic changes in infertile males with Kidney-Yang Deficiency syndrome are not well understood.
What are the changes in metabolites and metabolic pathways in the seminal plasma of infertile males with Kidney-Yang Deficiency syndrome compared to fertile males?
Case-Control (n=36)
What are the changes in metabolites and metabolic pathways in the seminal plasma of infertile males with Kidney-Yang Deficiency syndrome compared to fertile males?
Metabolomics analysis of seminal plasma identified 41 discriminating metabolites that may help differentiate TCM syndromes in infertile males with Kidney-Yang Deficiency.
Answers are grounded in this paper and cite their sources.
Supports metabolomics for TCM syndrome differentiation in male infertility; hypothesis-generating and should not yet change practice.
Traditional Chinese medicine (TCM) is an important treatment for male infertility, and its application to therapy is dependent on differentiation of TCM syndromes. This study aims to investigate the changes in metabolites and metabolic pathways in infertile males with Kidney-Yang Deficiency syndrome (KYDS) via metabolomics approaches. Seminal plasma samples were collected from 18 infertile males with KYDS and 18 fertile males. Liquid chromatography and mass spectrometry were used to characterize metabolomics profiles. Principal component analysis (PCA), partial least squares-discriminate analysis (PLS-DA), and pathway analysis were used for pattern recognition and metabolite identification. PCA and PLS-DA results differentiated the two groups of patients. Forty-one discriminating metabolites (18 in positive mode and 23 in negative mode) were identified. Seven metabolites were related to five potential metabolic pathways associated with biosynthesis and metabolism of aromatic amino acids, tricarboxylic acid cycle, and sphingolipid metabolism. The changes in metabolic pathways may play an important role in the origin of KYDS-associated male infertility. Metabolomics analysis of seminal plasma may be used to differentiate TCM syndromes of infertile males, but further research must be conducted.
No takes yet. Share an insight, caveat, or question.
Chen et al. (2015) conducted a case-control in Male infertility with Kidney-Yang Deficiency syndrome (n=36). Kidney-Yang Deficiency syndrome (KYDS) vs. Fertile males was evaluated on Changes in metabolites and metabolic pathways. Metabolomics analysis of seminal plasma identified 41 discriminating metabolites and 5 metabolic pathways that differentiated infertile males with Kidney-Yang Deficiency syndrome from fertile males.
Synapse has enriched 10 related papers. Consider them for comparative context: