Key result
Pediatric-protocol multimodality treatment fails to halt progression of adult primary pineal rhabdomyosarcoma.
Why the study?
Primary rhabdomyosarcoma of the pineal gland is a rare disease with poor prognosis and unknown optimal management.
Case Report (n=1)
Primary rhabdomyosarcoma of the pineal gland is a rare disease with a poor prognosis despite aggressive multimodality therapy.
Adds evidence of poor prognosis in primary pineal rhabdomyosarcoma despite therapy; leaves open avenues for novel interventions.
OBJECTIVES: To report a case of primary rhabdomyosarcoma (RMS) of the pineal gland in an adult, as well as review the literature on this rare entity. METHODS: The case is compared with previous reports of similar entities, with emphasis on this patient's characteristics and clinical presentation, investigations, and management. RESULTS: Diagnosis of primary RMS of the pineal gland was based on the presence of strap cells and multinucleated myotube-like structures, as well as tumor cell expression of skeletal muscle markers consistent with myogenic differentiation. Multimodality treatment was initiated based on pediatric protocols. Unfortunately, the disease progressed on treatment, and the patient survived only 5 months from diagnosis. CONCLUSIONS: Pineal RMS is a rare disease with poor prognosis. Optimal management is unknown but likely to involve aggressive multimodality therapy.
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Lau et al. (2015) conducted a case report in Primary rhabdomyosarcoma of the pineal gland (n=1). Multimodality treatment based on pediatric protocols was evaluated on Survival. Multimodality treatment based on pediatric protocols was initiated for an adult with primary pineal rhabdomyosarcoma, but the disease progressed and the patient survived only 5 months from diagnosis.
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