Key result
Thoracic epidural fentanyl shows no benefit over lumbar administration for pain control following elective thoracotomy.
Why the study?
The optimal epidural route for fentanyl administration after thoracotomy for postoperative analgesia was uncertain.
Does thoracic epidural fentanyl improve postoperative analgesia compared to lumbar epidural fentanyl in patients undergoing elective thoracotomy?
RCT (n=58)
Single-blind
Does thoracic epidural fentanyl improve postoperative analgesia compared to lumbar epidural fentanyl in patients undergoing elective thoracotomy?
Lumbar epidural fentanyl provides equivalent analgesia to thoracic epidural fentanyl following thoracotomy, avoiding the potentially more dangerous thoracic approach.
Supports lumbar over thoracic epidural fentanyl for thoracotomy analgesia to minimize risk; confirms equivalence without added benefit in this RCT.
Fifty-eight patients scheduled for elective thoracotomy were randomly allocated to receive fentanyl by either the thoracic or the lumbar epidural route for postoperative analgesia. The infusion rate was adjusted to optimise analgesia. Dose adjustment, pain assessment and the incidence of side effects were monitored by a blinded observer at set times over the 24 hour study period. Similar pain scores were obtained in both groups at all assessment times. In addition, there was no significant difference in dose requirements or incidence of side effects between the two groups. There appears little justification for the use of the generally less familiar, and potentially more dangerous, thoracic approach when fentanyl alone is infused into the epidural space following thoracotomy.
No takes yet. Share an insight, caveat, or question.
Coe et al. (1991) conducted an RCT in Postoperative pain following thoracotomy (n=58). Thoracic epidural fentanyl vs. Lumbar epidural fentanyl was evaluated on Pain scores. Thoracic epidural fentanyl resulted in similar pain scores, dose requirements, and side effects compared to lumbar epidural fentanyl following elective thoracotomy.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: