Key result
Direct hydrogen atom abstraction from the NG-hydroxyarginine O-H bond is not relevant to NOS mechanisms.
Why the study?
The mechanism of nitric oxide synthase and the relevance of direct hydrogen atom abstraction from the O−H bond of NG-hydroxyarginine were unclear.
Key points are not available for this paper at this time.
Comparison
Direct hydrogen atom abstraction from the O−H bond of NG-hydroxyarginine vs other mechanisms
Design
Mechanistic chemical study
Challenges proposed NOS mechanisms; leaves open the operative pathway for NO biosynthesis in cardiovascular research.
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTMechanism of Nitric Oxide Synthase. Evidence that Direct Hydrogen Atom Abstraction from the O−H Bond of NG-Hydroxyarginine Is Not Relevant to the MechanismHui Huang, Jung-Mi Hah, and Richard B. SilvermanView Author Information Department of Chemistry and Department of Biochemistry, Molecular Biology, and Cell Biology Northwestern University, Evanston, Illinois 60208-3113 Cite this: J. Am. Chem. Soc. 2001, 123, 11, 2674–2676Publication Date (Web):February 27, 2001Publication History Received19 December 2000Published online27 February 2001Published inissue 1 March 2001https://pubs.acs.org/doi/10.1021/ja005900uhttps://doi.org/10.1021/ja005900urapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1907Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (10)»Supporting Information Supporting Information SUBJECTS:Bond cleavage,Hydrogen abstraction,Oxides,Oxygen,Peptides and proteins Get e-Alerts
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Huang et al. (2001) studied this question. Direct hydrogen atom abstraction from the O-H bond of NG-hydroxyarginine is not relevant to the mechanism of nitric oxide synthase.
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