Key result
CABG linked to improved perfusion-metabolism mismatch mid-term, though mismatch persists in ~34% of patients.
Why the study?
Changes in myocardial metabolism after coronary revascularization by coronary artery bypass grafting are not fully elucidated.
Does isolated coronary artery bypass grafting improve myocardial perfusion-metabolism mismatch over time?
Cohort (n=38)
No
Does isolated coronary artery bypass grafting improve myocardial perfusion-metabolism mismatch over time?
Fatty acid metabolism disturbance improves from short- to mid-term after successful CABG, but impaired metabolism may persist in patients with severe atherosclerosis despite resolution of ischemia.
Answers are grounded in this paper and cite their sources.
CABG-linked mismatch reduction may leave metabolic impairment unresolved in one-third; leaves open need for adjunctive strategies in severe atherosclerosis.
OBJECTIVE: Myocardial ischemia is known to suppress fatty acid metabolism and favor glucose metabolism. However, changes in myocardial metabolism after coronary revascularization are not fully elucidated. METHODS: I-BMIPP SPECT in both the short-term (6.4 ± 4.7 months) and mid-term (29.9 ± 7.2 months) after isolated coronary artery bypass grafting. Tracer uptake was graded using a 17-segment, 5-point scoring model. Serial changes in SRS (summed rest score), SDS (summed difference score), the BMIPP score (total defect score of BMIPP), and the mismatch score (BMIPP score-SRS) were evaluated. In addition, persistent perfusion-metabolism mismatch (PM) was defined as mismatch score minus SDS of 3 or more during the mid-term postoperative period. The clinical parameters associated with PM were examined. RESULTS: From short- to mid-term postoperative period, the extent of infarcted myocardium (SRS) did not change significantly (7.8 ± 8.0 to 7.1 ± 7.0, P = 0.117). The extent of ischemic myocardium (SDS), the BMIPP score and the mismatch score, which reflects perfusion-metabolism mismatch, were significantly improved (2.0 ± 2.8 to 0.7 ± 1.0, P = 0.010; 12.2 ± 9.0 to 9.5 ± 7.9, P < 0.001; 4.4 ± 3.7 to 2.5 ± 2.6, P < 0.001; respectively). Remarkably, perfusion-metabolism mismatch persisted in 13 patients (34%) even in the mid-term postoperative period. eGFR and SYNTAX score were independent predictors of persistent perfusion-metabolic mismatch in multivariable analysis (OR = 0.951, 95% CI 0.898-0.985, P = 0.010 and OR = 1.126, 95% CI 1.011-1.254, P = 0.031, respectively). The mismatch score both in the short- and mid-term significantly correlated with SYNTAX score (r = 0.400 and r = 0.472, respectively). CONCLUSIONS: Fatty acid metabolism disturbance improved from short- to mid-term postoperative period in patients with successful reperfusion by coronary artery bypass grafting. However, in patients with severe atherosclerosis, impaired fatty acid metabolism was sustained until the mid-term postoperative period, even though ischemia had resolved.
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Morishima et al. (2021) conducted a cohort in Coronary artery disease (n=38). Coronary artery bypass grafting vs. Short-term postoperative period was evaluated on Serial change in mismatch score (perfusion-metabolism mismatch) (p=<0.001). Perfusion-metabolism mismatch improved from the short- to mid-term postoperative period after coronary artery bypass grafting, though mismatch persisted in 34% of patients.
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