Key result
Bariatric surgery linked to ~68% excess weight loss and improved insulin sensitivity at 1 year.
Why the study?
The effect of massive weight loss on insulin resistance and its correlation with glycemic homeostasis and lipid profile changes in severely obese patients was assessed.
Does silastic ring vertical gastroplasty Roux-en-Y gastric bypass surgery improve insulin resistance, glycemic homeostasis, and lipid profiles in morbidly obese women?
Population
31 morbidly obese women with BMI 54.2 +/- 8.8 kg/m2 divided by glucose tolerance status
Comparison
Preoperative versus postoperative insulin tolerance test results after bariatric surgery
Design
Prospective clinical intervention study
Follow-up
12 months
Authors
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Bariatric surgery was associated with glycemic gains in obese women; extends observational data but leaves open need for RCTs before practice change.
Observational (n=31)
Does silastic ring vertical gastroplasty Roux-en-Y gastric bypass surgery improve insulin resistance, glycemic homeostasis, and lipid profiles in morbidly obese women?
Bariatric surgery significantly reduces weight and improves insulin sensitivity, glycemic control, and lipid profiles across a range of baseline glucose tolerance statuses in morbidly obese women.
Geloneze et al. (2001) conducted an observational in Morbid obesity (n=31). Bariatric surgery (silastic ring vertical gastroplasty Roux-en-Y gastric bypass) vs. Baseline (pre-surgery) was evaluated on Reduction in initial excess body weight. Bariatric surgery in morbidly obese women led to a 68% reduction in initial excess body weight at 1 year, alongside significant improvements in insulin sensitivity and metabolic parameters.
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