Key result
Fibroblastic reticular cells in fat-associated lymphoid clusters orchestrate protective peritoneal immune responses via MYD88 expression.
Why the study?
The role of fibroblastic reticular cells in fat-associated lymphoid clusters as initial checkpoints for protective immune responses in the peritoneal cavity was unclear.
Key points are not available for this paper at this time.
Comparison
Mice lacking MYD88 expression in FRCs vs normal mice
Design
Experimental study in mice
FRCs in FALCs may represent immunomodulatory targets in peritoneal infection; leaves open human translation and therapeutic relevance.
infection was compromised in mice lacking MYD88 expression in FRCs, indicating that FRCs in FALCs function as an initial checkpoint in the orchestration of protective immune responses in the peritoneal cavity.
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Perez‐Shibayama et al. (2018) studied this question. Fibroblastic reticular cells in fat-associated lymphoid clusters act as an initial checkpoint to orchestrate protective immune responses in the peritoneal cavity via MYD88 expression.
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