Key result
Taohong Siwu decoction reveals 45 interactive targets for androgenetic alopecia, highlighting luteolin and quercetin.
Why the study?
The molecular mechanisms and targets of Taohong Siwu decoction in treating androgenetic alopecia were not fully elucidated.
Network pharmacology and molecular docking suggest that Taohong Siwu decoction may treat androgenetic alopecia through anti-inflammatory and anti-oxidative pathways involving targets like AKT1 and TP53.
Hypothesis-generating for Taohong Siwu decoction in androgenetic alopecia; human trials needed before clinical consideration.
Purpose: Taohong Siwu decoction (THSWD) is traditionally used to treat androgenic alopecia (AGA) in clinical practice of traditional Chinese medicine. This study used a network pharmacology approach to elucidate the molecular mechanism governing the effect of THSWD on AGA. Materials and Methods: The major active components and their corresponding targets of THSWD were screened. AGA-related targets were obtained by analyzing the differentially expressed genes between AGA patients and healthy individuals. The protein-protein interaction networks of putative targets of THSWD and AGA-related targets were visualized and merged to identify the candidate targets for THSWD against AGA. Gene ontology (GO) biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis for core targets were performed. Finally, the key effective components and core targets screened were verified by molecular docking. Results: In this study, 69 compounds and 202 compound targets of THSWD, as well as 1158 disease targets, were screened. Forty-five interactive targets were identified for constructing the "ingredient-targets" network. The functional annotations of target genes were found to be related to oxidative stress, reactive oxygen species, and hydrogen peroxide. Pathways involved in the treatment of AGA included apoptosis and PI3K-AKT signaling pathways. The luteolin, quercetin, kaempferol, baicalein, and beta-carotene were identified as the vital active compounds, and AKT1, TP53, JUN, CASP3 and MYC were considered as the core targets. Assessment of molecular docking revealed that these active compounds and targets had good-binding interactions. Conclusion: The results indicated that the effects of THSWD against AGA may be related to anti-inflammation and anti-oxidation properties of the compounds through the specific biological processes and the related pathways.
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Tan et al. (2022) studied androgenetic alopecia (AGA). Taohong Siwu decoction (THSWD) was evaluated on active components and core targets. Network analysis identified 69 compounds and 202 targets of Taohong Siwu decoction, with 45 interactive targets for androgenetic alopecia, highlighting luteolin and quercetin as key active compounds.
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