Key result
Ablation of fractionated potentials with conduction delay during rapid pacing successfully treats longstanding persistent AF.
Why the study?
A fractionated potential with conduction delay during rapid pacing in the atrium might be the origin and substrate of longstanding atrial fibrillation, but its role in treatment is unclear.
Ablation targeting fractionated potentials with conduction delay during rapid pacing may be an effective strategy for treating longstanding persistent atrial fibrillation.
Single-case observations implicate fractionated potentials in AF substrate; leaves open whether targeting them alters ablation outcomes.
•AF promotes atrial fibrosis, which is thought to play an important role in AF formation and maintenance.•A short-coupling interval stimulus prolongs the PV and atrial conduction time, which is correlated to AF vulnerability and recurrence.•A fractionated potential with conduction delay during rapid pacing in the atrium might be the origin and substrate of longstanding AF.
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Mikami et al. (2023) studied this question. Ablation of fractionated potentials with conduction delay during rapid pacing successfully treated longstanding persistent atrial fibrillation.
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