Through the novel technique of high speed ball milling we were able to generate Baylis–Hillman products in as little as 0.5 hours. This represents one of the fastest methods of Baylis–Hillman reactions under neat conditions. Upon analysis of various catalysts we found 1,4-diazabicyclo[2.2.2]octane to be the catalyst that led to the highest product yields in the shortest reaction time.
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Mack et al. (2007) studied this question.
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