Synthesis, Characterization and Biological Evaluation of Some Benzothiazole Derivatives as Potential Antimicrobial Agent.

A new series of benzylidine-2-imino-6-nitro-1,3-benzothiazole , benzylidine-2-imino-6-methoxy-1,3benzothiazole and benzylidine-2-imino-6-methyl-1,3-benzothiazole was synthesised by condensation with different aromatic aldehydes.The target molecules were synthesised by using different reaction conditions and greener approach.The products were readily obtained with 70-85 % yield.The structures of synthesized compounds were confirmed by physical, chemical and FT-IR, 1 H-NMR, LCMS, etc. spectroscopic techniques.The synthesized compounds were tested against representatives of gram-positive and gram-negative bacteria (staphylococcus aureus and Basillus subtilis.) by agar diffusion method using Amicacin and Gentamycin as control.The results indicate that the compounds possessed a broad spectrum of activity against the tested microorganisms.