Key result
Fibrinogen concentration drives platelet aggregation velocity in a bell-shaped response peaking at hemisaturating doses.
Why the study?
The influence of plasma fibrinogen concentration on the velocity of platelet aggregation and its relationship with fibrinogen binding to platelets was unclear.
Does fibrinogen concentration affect the velocity of platelet aggregation in gel-filtered platelets?
Does fibrinogen concentration affect the velocity of platelet aggregation in gel-filtered platelets?
Plasma fibrinogen concentration has a major influence on the velocity of platelet aggregation, demonstrating a bell-shaped response curve.
Answers are grounded in this paper and cite their sources.
Should not alter clinical platelet testing; hypothesis-generating for fibrinogen modulation in aggregation models.
The relationship between fibrinogen binding to its receptor and platelet aggregation has been investigated by comparing 125I-fibrinogen binding and aggregation velocities of gel-filtered platelets in the presence of adenosine diphosphate (ADP). Aggregometric responses at various fibrinogen concentrations are found to be bell-shaped and show a maximum at fibrinogen concentrations (Fmax) similar to the 125I- fibrinogen hemisaturating doses. At higher and lower fibrinogen concentrations, platelet aggregation velocities decrease in a parallel manner. Lowering ADP concentration increases Fmax, in agreement with the modulatory effect of ADP on fibrinogen binding to platelets. Variations of fibrinogen in the range of physiopathologic plasma concentrations affect platelet aggregation induced by any ADP dose. These results clarify the relationship between the fibrinogen binding process and aggregation and demonstrate that plasma fibrinogen concentration has a major influence on the velocity of platelet aggregation.
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Landolfi et al. (1991) studied this question. Fibrinogen concentration vs. Various concentrations was evaluated on Velocity of platelet aggregation and 125I-fibrinogen binding. Fibrinogen concentration has a major influence on the velocity of platelet aggregation, demonstrating a bell-shaped aggregometric response that peaks at hemisaturating doses.
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