Key result
Amiodarone use is linked to bone marrow granulomas that resolve after drug withdrawal.
Why the study?
Amiodarone-induced bone marrow granulomas have not been well characterized in patients treated for atrial fibrillation.
Case Report (n=2)
Amiodarone may cause bone marrow granulomas that resolve upon drug withdrawal.
May prompt vigilance for amiodarone-related granulomas; case reports leave causality hypothesis-generating.
Amiodarone hydrochloride, a class III antiarrhythmic agent used to treat supraventricular and ventricular cardiac dysrhythmias. In this report we describe two patients receiving amiodarone for atrial fibrillation who underwent bone marrow biopsies to investigate paraproteinaemia (case 1) or severe thrombocytopenia (case 2). Multiple bone marrow granulomas were found in both patients, without evidence of any other cause. In both patients the granulomas disappeared after amiodarone withdrawal, suggesting a direct association.
No takes yet. Share an insight, caveat, or question.
Boutros et al. (2000) conducted a case report in Atrial fibrillation (n=2). Amiodarone was evaluated on Bone marrow granulomas. Amiodarone use was associated with the development of multiple bone marrow granulomas in two patients, which disappeared after drug withdrawal.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: