Key result
Suppressed EEG during ECMO is linked to ~10-fold higher odds of poor 3-month neurological outcomes.
Why the study?
Neurologic injury is a frequent cause of death in ECMO patients, and the value of EEG monitoring in adult ECMO patients has not been well assessed.
Are specific electroencephalographic abnormalities associated with unfavorable neurological outcome in adult patients treated with ECMO?
Observational (n=139)
No
Are specific electroencephalographic abnormalities associated with unfavorable neurological outcome in adult patients treated with ECMO?
Odds Ratio: 10.08 (95% CI 1.24–82.2)
Absolute Event Rate: 100% vs 59.8%
p-value: p=0.03
In adult patients on ECMO, a suppressed EEG background is strongly associated with an unfavorable neurological outcome at 3 months.
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May inform prognosis in ECMO; hypothesis-generating and requires prospective validation before guiding care.
Peluso et al. (2020) conducted an observational in Extracorporeal membrane oxygenation (ECMO) (n=139). Suppressed EEG background vs. Mild/moderate encephalopathy was evaluated on Unfavorable neurological outcome (Glasgow Outcome Scale < 4) at 3 months (OR 10.08, 95% CI 1.24-82.20, p=0.03). In adult patients undergoing extracorporeal membrane oxygenation, a suppressed EEG background was independently associated with an unfavorable neurological outcome at 3 months (OR 10.08).
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