Key result
Local irradiation establishes a rat model to study radiation sensitivity in alloxan-induced diabetes.
Why the study?
Diabetic patients appear less able to tolerate radiation than nondiabetics, but this intolerance is little documented and lacks experimental correlation in animals.
Does alloxan-induced diabetes increase local radiation sensitivity in rats?
Comparison
Alloxan-induced diabetic rats vs non-diabetic rats receiving local irradiation
Design
Preclinical experimental study with local irradiation
Follow-up
One to six weeks
Authors
Loading...
May warrant caution with pelvic radiation in diabetics; leaves open confirmation via prospective trials.
Does alloxan-induced diabetes increase local radiation sensitivity in rats?
This preliminary study describes an experimental alloxan-induced diabetic rat model to investigate whether diabetes increases sensitivity to local irradiation.
Gunn et al. (1967) studied Diabetes (n=52). Local irradiation vs. Nondiabetic irradiated rats was evaluated. Local irradiation of 1,000 to 7,000 R was administered to 52 Fischer male rats to establish an experimental model for studying radiation sensitivity in alloxan-induced diabetes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: